Tofacitinib Citrate Uses and Mechanism of Action

Tofacitinib citrate is an innovative Janus kinase (JAK) inhibitor that has revolutionized the treatment of several autoimmune conditions. This comprehensive guide explores the clinical applications, pharmacological mechanism, dosage forms, and safety profile of Tofacitinib citrate, providing healthcare professionals with essential information about this breakthrough medication developed by Run'an Pharmaceutical.

Clinical Applications of Tofacitinib Citrate

Tofacitinib citrate is FDA-approved for multiple therapeutic indications with proven efficacy in:

Moderate to severe active RA in adults

Methotrexate combination or monotherapy

Reduces joint swelling and progression of structural damage

Active PsA in patients with inadequate response to DMARDs

Improves enthesitis and dactylitis

Moderate to severe active UC

Induction and maintenance of remission

Ankylosing spondylitis

Alopecia areata

Juvenile idiopathic arthritis

Pharmacological Mechanism of Action

Tofacitinib citrate exerts its therapeutic effects through:

Selective inhibition of JAK1 and JAK3

Modulation of cytokine signaling (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21)

Reduction of inflammatory mediators

Decreases circulating CD16+/CD56+ NK cells

Reduces serum C-reactive protein (CRP) levels

Lowers matrix metalloproteinase (MMP) levels

Safety Profile and Risk Management

Upper respiratory tract infections (15-20%)

Headache (4-7%)

Diarrhea (3-5%)

Increased LDL cholesterol (10-15%)

✔ Herpes zoster reactivation
✔ Thromboembolic events
✔ Lymphoma and other malignancies
✔ Gastrointestinal perforations

Why Choose Run'an Pharmaceutical's Tofacitinib Citrate?

✔ cGMP-certified manufacturing facilities
✔ Strict quality control exceeding pharmacopeial standards
✔ Comprehensive stability studies
✔ Global regulatory compliance (FDA, EMA, PMDA)
✔ Competitive pricing for healthcare systems

For product information, clinical data, or partnership opportunities:

As the Chief Scientific Officer at Run'an Pharmaceutical with 20 years of experience in immunomodulatory therapies, I personally guarantee the quality and efficacy of our Tofacitinib citrate formulations. Contact our medical affairs team today to discuss how we can support your therapeutic needs.