How Does CAS 288‑94‑8 (Tetrazole) Enable Breakthroughs in Pharmaceutical Synthesis?

Run'an Pharmaceutical presents CAS 288‑94‑8, also known as 1H‑Tetrazole, a high‑purity white to light‑yellow crystalline powder with the molecular formula CH₂N₄ and molecular weight 70.05. This versatile heterocyclic building block is indispensable in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Manufactured in Run'an's state‑of‑the‑art API production facility—equipped with DCS automated control and compliant with FDA, Japan, and South Korea GMP standards—this product reflects the company's commitment to quality, safety, and international sustainability. With a 25,000 m² production base and a robust environmental compliance record, Run'an ensures reliable supply for global pharmaceutical partners.

Tetrazole: A Versatile Heterocyclic Core

CAS 288‑94‑8, systematically named 1H‑1,2,3,4‑Tetrazole, is a five‑membered aromatic heterocycle containing four nitrogen atoms. Its unique structure imparts high acidity and remarkable stability, making it a privileged scaffold in medicinal chemistry. The compound serves as a bioisostere for carboxylic acids, enhancing metabolic stability and binding affinity in drug candidates. Run'an Pharmaceutical produces this key intermediate with exceptional purity, meeting stringent specifications for pharmaceutical R&D and commercial production. The product is supplied as an odourless, free‑flowing crystalline powder, easy to handle and formulate in various synthetic routes.

Key Technical Specifications

Applications in Pharmaceutical and Chemical Industries

Tetrazole and its derivatives are widely employed in the synthesis of active pharmaceutical ingredients (APIs), including:

• Antihypertensive agents – Losartan, valsartan, and other sartans rely on tetrazole as a critical pharmacophore for AT₁ receptor antagonism.

• Antibiotics – Tetrazole‐containing cephalosporins and other β‑lactam derivatives exhibit enhanced antibacterial activity.

• Anti‑inflammatory and anticancer drugs – Tetrazole rings are incorporated into COX‑2 inhibitors and kinase modulators.

• Agrochemicals – Used in the synthesis of herbicides, fungicides, and plant growth regulators.

Run'an Pharmaceutical supplies this intermediate to clients in Japan, South Korea, Spain, and other regions, supporting both early‑stage R&D and commercial manufacturing with consistent quality and full regulatory traceability.

Run'an Pharmaceutical: A State‑of‑the‑Art API Manufacturer

Jiangsu Run'an Pharmaceutical Co., Ltd., a wholly‑owned subsidiary of Jiangsu Zhengda Qingjiang Pharmaceutical Co., Ltd., was established to extend the industrial chain, ensure raw material supply security, and accelerate new product industrialisation. The project broke ground in November 2018 on a 59‑acre site with a total investment of RMB 160 million. The facility encompasses approximately 25,000 m² of constructed area, including general API and anti‑tumour API production workshops, a fermentation workshop, an R&D centre, a comprehensive quality inspection lab, and supporting utilities (warehousing, water, electricity, gas, sewage treatment). The entire production process is controlled by an advanced DCS system, achieving domestic leading automation standards.

The company's product portfolio includes gemcitabine hydrochloride, celecoxib, bromhexine hydrochloride, risedronate sodium, iguratimod, apremilast, tofacitinib citrate, sugammadex sodium, urapidil hydrochloride, linagliptin, and allicin, among others. With a complete quality management system that meets FDA, Japanese, and Korean GMP requirements, multiple product registrations have already been approved, positioning Run'an as a reliable partner for global pharmaceutical companies.

Commitment to Safety and Environmental Stewardship

Since completing construction and passing acceptance inspections in July 2020, Run'an Pharmaceutical has systematically secured all necessary regulatory approvals, demonstrating its unwavering dedication to safety, environmental protection, and occupational health. Key milestones include:

• Lightning protection device acceptance by Huai'an Meteorological Bureau (April 2020)
• Fire acceptance for Class C and Class A buildings (May–June 2020)
• Environmental emergency plan filing and Pollution Discharge Permit issuance (June–July 2020)
• Safety expert reviews for trial production plans, emergency response plans, and safety facility completion acceptance (September–December 2020)
• Occupational health control effect review and all normative acceptance completed by February 2021

The company adheres to the principle of "caring for life, green development, and international sustainable development", ensuring that every batch of CAS 288‑94‑8 is produced under the highest environmental and safety standards.

Frequently Asked Questions

Q: What is the purity of Run'an's CAS 288‑94‑8?

A: Our tetrazole is routinely supplied with ≥99.0% purity (HPLC). Higher purity grades can be customised upon request.

Q: Is this product suitable for GMP pharmaceutical manufacturing?

A: Yes. Run'an's facility is built to FDA, Japan, and South Korea GMP standards, and we provide full documentation for regulatory submissions.

Q: What packing options are available?

A: We offer flexible packaging—from lab‑scale containers (e.g., 100g, 500g) to industrial drums (25kg, 50kg, or custom) with appropriate moisture‑proof liners.

Q: Can you provide samples for analytical testing?

A: Yes, sample quantities are available upon request. Please contact our sales team to arrange.

Q: Is the manufacturing facility audited by regulatory agencies?

A: Yes, our site has passed multiple inspections and accepts customer audits. We also hold valid Pollution Discharge Permit and all required safety/environmental certifications.

Conclusion

To conclude, Run'an Pharmaceutical's CAS 288‑94‑8 (1H‑Tetrazole) represents a reliable, high‑purity building block for advanced pharmaceutical synthesis, backed by a modern, DCS‑controlled facility and a strong record of regulatory compliance. With a dedicated R&D centre, comprehensive quality systems, and a clear focus on sustainable development, Run'an is positioned to support your most challenging projects. For technical enquiries, samples, or bulk order quotations, please reach out to our international sales team—we look forward to collaborating with you and providing the quality you expect.