CAS 141-86-6

2,6-diamino-pyridin

Diaminopyridine

Pyridine, 2,6-diamino-

pyridine-2,6-diyldiamine

2 6-DIAMINOPYRIDINE 99+% &

2,6-Diaminopyridine,>98%

2,6-DAP

2,6-Diaminopyridine

2,6-Pyridinediamine

6-Amino-2(1H)-pyridinimine

Molecular formula: C5H7N3

Molecular weight: 109.13

CAS 141-86-6 is intermediate for hair dye products.

Structure：

CAS 141-86-6: Applications, Advantages, and Challenges in Modern Chemistry

Introduction

CAS 141-86-6, chemically identified as 2-aminopyrimidine, is a heterocyclic organic compound with a wide range of applications in pharmaceuticals, agrochemicals, and materials science. Its unique structure—combining a pyrimidine ring with an amino group—grants it versatility as a building block in synthetic chemistry. This article explores the key uses, benefits, and limitations of CAS 141-86-6, highlighting its significance across industries.

Applications of CAS 141-86-6

Pharmaceutical Synthesis

CAS 141-86-6 is a critical intermediate in drug development. It serves as a precursor for antiviral and anticancer agents, including nucleoside analogs. For example, its derivatives are incorporated into drugs targeting RNA viruses by mimicking pyrimidine bases, disrupting viral replication.

Agrochemical Formulations

In agriculture, CAS 141-86-6 is used to synthesize herbicides and fungicides. Its ability to bind to enzymes in plant pathogens enhances the efficacy of crop protection agents while minimizing environmental persistence.

Coordination Chemistry

The amino and nitrogen-rich structure of CAS 141-86-6 makes it a valuable ligand in metal-organic frameworks (MOFs) and catalysts. These materials are employed in gas storage, catalysis, and sensors.

Biochemical Research

Researchers utilize CAS 141-86-6 to study enzyme inhibition mechanisms, particularly in kinases and dehydrogenases, aiding the discovery of targeted therapies for metabolic disorders.

Advantages of CAS 141-86-6

Structural Versatility

The dual functional groups of CAS 141-86-6 enable diverse chemical modifications, allowing chemists to tailor derivatives for specific applications, from drug candidates to advanced materials.

Cost-Effective Synthesis

Compared to complex heterocycles, CAS 141-86-6 can be synthesized via straightforward routes, such as the condensation of amidines with β-diketones, reducing production costs.

High Reactivity

The electron-rich pyrimidine ring in CAS 141-86-6 facilitates electrophilic substitution reactions, accelerating the synthesis of functionalized compounds.

Low Environmental Persistence

Unlike halogenated analogs, CAS 141-86-6 degrades more readily in natural conditions, aligning with green chemistry principles.

Limitations of CAS 141-86-6

Toxicity Concerns

Prolonged exposure to CAS 141-86-6 may pose health risks, including respiratory and skin irritation, necessitating strict handling protocols in industrial settings.

Solubility Challenges

The limited solubility of CAS 141-86-6 in polar solvents complicates its use in aqueous reactions, often requiring organic solvents that raise safety and disposal concerns.

Stability Issues

Under acidic or high-temperature conditions, CAS 141-86-6 can undergo decomposition, restricting its utility in certain synthetic pathways.

Regulatory Hurdles

While CAS 141-86-6 is widely used, evolving regulations on amine-containing compounds may impact its accessibility in regions with stringent chemical controls.

Future Prospects

Innovations in the application of CAS 141-86-6 are focused on overcoming its limitations. For instance:

Nanocarrier Systems: Encapsulating CAS 141-86-6 to enhance solubility and reduce toxicity.

Sustainable Synthesis: Developing solvent-free or biocatalytic methods to produce CAS 141-86-6 with lower environmental impact.

AI-Driven Drug Design: Leveraging CAS 141-86-6’s scaffold to generate novel bioactive molecules via computational modeling.

As demand for precision chemicals grows, CAS 141-86-6 is poised to remain a cornerstone of industrial and pharmaceutical chemistry.